Over the past few years, particular interest has been paid towards the fabrication of new Drug Delivery Systems (DDS) to specifically deliver the therapeutic agents to target sites [1, 2]. This technology offers great advantages over conventional DDS such as low toxicity, wide therapeutic window, minimized side effects, ideal drug efficacy and releasing drugs in a sustained rate [3]. Multifarious carrier systems can be formed with the help of montmorillonite (Mt) to deliver drug effectively. Controlled release of drugs from bio-composites made up of polymer and montmorillonite has been studied extensively since last few years. We choose in this work to speak about two bio-composites systems which are: Montmorillonite Ibuprofen/Carboxymethylcellulose noted: (MtIb/CMC) and montmorillonite Diclofenac/Carboxymethyl cellulose noted: (MtDS/CMC). We first intercalated the drugs onto Mt galleries and then added polymer in solution to obtain final systems.

The new polymer/(clay-drug) bio-composites were characterized by FT-IR, XRD, DSC and TGA techniques. Both the XRD and differential scanning calorimetric (DSC) studies revealed that the intercalation of the drugs between the clay layers induced their amorphization . A study of the release of both drugs from the synthesized biocomposites in simulated intestinal fluid (pH 7.4) was investigated.